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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AA1
All Species:
25.76
Human Site:
S63
Identified Species:
43.59
UniProt:
P07900
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07900
NP_001017963.2
732
84660
S63
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
S63
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Rhesus Macaque
Macaca mulatta
XP_001098520
724
83571
S63
Y
E
S
L
T
D
P
S
K
L
D
S
G
K
E
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P07901
733
84769
S63
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Rat
Rattus norvegicus
P82995
733
84796
S63
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512830
733
84847
S63
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Chicken
Gallus gallus
P11501
728
84041
L63
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
D
Frog
Xenopus laevis
NP_001085598
729
84174
S64
L
D
K
I
R
Y
E
S
L
T
D
P
S
K
L
Zebra Danio
Brachydanio rerio
Q90474
725
83300
D63
I
R
Y
E
S
L
T
D
P
S
K
L
D
S
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
L68
G
K
E
L
Y
I
K
L
I
P
N
K
T
A
G
Honey Bee
Apis mellifera
XP_395168
718
82735
S63
Y
E
S
L
T
D
P
S
K
L
D
N
G
K
E
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
E63
S
E
L
D
T
G
K
E
L
F
I
K
I
T
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
D63
I
R
F
E
S
L
T
D
K
S
N
V
N
A
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P27323
700
80617
L63
K
L
D
G
Q
P
E
L
F
I
R
L
V
P
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
83
N.A.
N.A.
99
99.1
N.A.
95.9
96.1
91.9
85.3
N.A.
77.5
81.2
74.4
N.A.
Protein Similarity:
100
99.7
90.1
N.A.
N.A.
99.7
99.7
N.A.
98.2
97.6
96
93.5
N.A.
88.1
90.4
86
N.A.
P-Site Identity:
100
100
20
N.A.
N.A.
100
100
N.A.
100
0
100
0
N.A.
0
20
6.6
N.A.
P-Site Similarity:
100
100
33.3
N.A.
N.A.
100
100
N.A.
100
0
100
13.3
N.A.
40
33.3
20
N.A.
Percent
Protein Identity:
N.A.
68.5
N.A.
70.2
N.A.
N.A.
Protein Similarity:
N.A.
82.5
N.A.
82.9
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
43
8
8
0
15
0
15
0
8
58
0
8
0
15
% D
% Glu:
0
22
8
15
0
8
50
8
0
0
0
0
0
0
15
% E
% Phe:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
8
0
0
0
0
0
0
15
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
8
43
0
8
0
0
8
8
8
0
8
0
0
% I
% Lys:
8
15
43
0
0
0
15
0
22
0
8
15
8
58
0
% K
% Leu:
43
8
8
22
0
15
0
22
50
15
0
15
0
8
43
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
15
8
8
0
0
% N
% Pro:
0
0
0
0
0
8
15
0
8
8
8
43
0
8
8
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
15
0
8
43
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
8
0
15
0
15
0
8
58
0
15
0
15
43
8
0
% S
% Thr:
0
0
0
0
22
0
15
0
8
43
0
0
8
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
0
8
0
15
43
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _